Tricky Question
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Online Science Education :: Subjects :: Biology :: Genetics :: 1 on 1 Tutoring
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Tricky Question
Hi,
I have this qn that dosent seem to give me enough info to work it out (though I suppose it does and I just cant do it)
-94,075 babies born over a period of time. Then were diagnosed as achondroplastic dwarfs, an autosomal dominant trait showing full penetrance. Only two dwarfs had a dwarf parent. What is the mutation frequency in the gametes? Assume all mutations occured in the gametes.
Im not sure what to do.
Thanks for any help
I have this qn that dosent seem to give me enough info to work it out (though I suppose it does and I just cant do it)
-94,075 babies born over a period of time. Then were diagnosed as achondroplastic dwarfs, an autosomal dominant trait showing full penetrance. Only two dwarfs had a dwarf parent. What is the mutation frequency in the gametes? Assume all mutations occured in the gametes.
Im not sure what to do.
Thanks for any help
georgina_009- Student
- Posts : 25
Join date : 2008-03-18
Re: Tricky Question
I think there is a type-o in this question. It probably should say ten not then: "Ten were diagnosed as achondroplastic dwarfs". If so, then 10-2=8 (exclude those with dwarf parents) => 8 out of 94,075 are mutation products. With 2 parents per baby there are 94,075x2=188,150 gametes and since it is a dominant trait only 8 gametes were mutant. Thus, 8/188,150= 0.0000425 is the frequency of the mutation.
Alla- Instructor
- Posts : 103
Join date : 2008-02-27
Re: Tricky Question
Oh yeah. Thanks, I probably should have thought of that! Thanks for your help
georgina_009- Student
- Posts : 25
Join date : 2008-03-18
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